The Calu-6 cell line is a human non-small cell lung cancer (NSCLC) cell line derived from a 58-year-old Caucasian female patient with lung adenocarcinoma. Calu-6 cells are often used as an in vitro model system for studying lung cancer biology, molecular mechanisms, and potential therapeutics.

Non-small cell lung cancer is the most common type of lung cancer, accounting for about 85% of all lung cancer cases. There are several subtypes of NSCLC, including adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Adenocarcinoma, the subtype from which Calu-6 cells were derived, is the most common form of NSCLC and is often found in the outer parts of the lung.

Calu-6 cells have been used in numerous studies to investigate various aspects of lung cancer biology, including the role of oncogenes, tumor suppressor genes, and signaling pathways in cancer development and progression. Moreover, these cells have been utilized to test the efficacy of potential anti-cancer drugs and to study drug resistance mechanisms. The Calu-6 cell line is valuable for researchers working in the field of lung cancer due to its relevance to the disease and its ability to provide insights into the molecular mechanisms underlying cancer progression and response to therapy.