The DMS 273 cell line, also known as DMS-273, is a human small-cell lung cancer (SCLC) cell line. It was derived from a 70-year-old male patient with small-cell lung carcinoma. SCLC is a less common but more aggressive form of lung cancer compared to non-small cell lung cancer (NSCLC), accounting for about 15% of all lung cancer cases. SCLC usually originates in the central parts of the lung and is strongly associated with cigarette smoking.

DMS 273 cells are used as an in vitro model system for studying small-cell lung cancer biology, molecular mechanisms, and potential therapeutics. This cell line is particularly useful for understanding the differences between small-cell and non-small-cell lung cancers, as they have distinct molecular and histological features.

Researchers have utilized the DMS 273 cell line in various studies to investigate the role of oncogenes, tumor suppressor genes, and signaling pathways in small-cell lung cancer development and progression. Additionally, these cells have been employed to test the efficacy of potential anti-cancer drugs and to study drug resistance mechanisms specific to small-cell lung cancer.

In summary, the DMS 273 cell line is a valuable tool for researchers working in the field of lung cancer, as it provides insights into the biology and molecular mechanisms underlying small-cell lung cancer and aids in the development and testing of potential therapeutic strategies.