The H460 cell line is a human cancer cell line derived from a patient with large-cell lung carcinoma. It is also known as NCI-H460 or simply H460. This cell line is widely used in cancer research, particularly in studying lung cancer, drug resistance, and the development of novel therapeutics.
The H460 cell line exhibits characteristics of large-cell lung carcinoma, which is a subtype of non-small cell lung cancer (NSCLC). This cancer subtype is characterized by the lack of glandular or squamous differentiation and is often associated with a poor prognosis.
Researchers use the H460 cell line for various purposes, including:
- Investigating the molecular mechanisms underlying lung cancer development and progression.
- Studying the cellular response to chemotherapeutic agents and developing strategies for overcoming drug resistance.
- Evaluating the efficacy of novel anticancer therapeutics and treatment strategies in vitro before moving on to in vivo models.
- Identifying and validating potential therapeutic targets and biomarkers for lung cancer.
Using the H460 cell line, along with other lung cancer cell lines, has contributed to the advancement of knowledge in the field of lung cancer research and has helped in the development of more effective treatment options for patients.